0000950170-22-016258 | 10-Q | XBRL Viewer

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Document and Entity Information - shares	6 Months Ended
Document and Entity Information - shares	Jun. 30, 2022	Jul. 31, 2022
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2022
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q2
Entity Registrant Name	CULLINAN ONCOLOGY, INC.
Current Fiscal Year End Date	--12-31
Document Quarterly Report	true
Document Transition Report	false
Entity Central Index Key	0001789972
Entity File Number	001-39856
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	81-3879991
Entity Address, Address Line One	One Main Street
Entity Address, Address Line Two	Suite 520
Entity Address, City or Town	Cambridge
Entity Address, Country	MA
Entity Address, Postal Zip Code	02142
City Area Code	(617
Local Phone Number	410-4650
Title of 12(b) Security	Common Stock, par value $0.0001 per share
Trading Symbol	CGEM
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		45,612,205

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 353,563	$ 59,774
Short-term investments	257,432	230,692
Prepaid expenses and other current assets	11,846	6,098
Total current assets	622,841	296,564
Property and equipment, net	52	77
Operating lease right-of-use assets	1,074	0
Other assets	100	147
Long-term investments	43,182	140,397
Total assets	667,249	437,185
Current liabilities:
Accounts payable	3,099	3,169
Accrued expenses and other current liabilities	11,901	8,577
Income tax payable	46,502	0
Operating lease liabilities, current	533	0
Total current liabilities	62,035	11,746
Long-term liabilities:
Operating lease liabilities, net of current portion	596	0
Deferred rent	0	65
Total liabilities	62,631	11,811
Commitments and contingencies (Note 11)
Stockholders' equity:
Common stock, $0.0001 par value, 150,000,000 shares authorized as of June 30, 2022 and December 31, 2021; 45,396,398 and 44,292,102 shares issued and outstanding as of June 30, 2022 and December 31, 2021, respectively.	5	4
Additional paid-in capital	604,275	584,714
Accumulated other comprehensive loss	(3,633)	(838)
Retained earnings (accumulated deficit)	3,891	(158,909)
Total Cullinan stockholders' equity	604,538	424,971
Noncontrolling interests	80	403
Total stockholders' equity	604,618	425,374
Total liabilities and stockholders' equity	$ 667,249	$ 437,185

CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Jun. 30, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	150,000,000	150,000,000
Common stock, shares issued	45,396,398	44,292,102
Common stock, shares outstanding	45,396,398	44,292,102

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Statement [Abstract]
Revenue	$ 0	$ 0	$ 0	$ 18,943
Type of revenue [Extensible List]	us-gaap:LicenseMember	us-gaap:LicenseMember	us-gaap:LicenseMember	us-gaap:LicenseMember
Operating expenses:
Research and development	$ 26,411	$ 11,778	$ 50,947	$ 24,193
General and administrative	10,695	4,826	18,816	9,982
Total operating expenses	37,106	16,604	69,763	34,175
Gain on sale of Cullinan Pearl	276,785	0	276,785	0
Income/(loss) from operations	239,679	(16,604)	207,022	(15,232)
Other income (expense):
Interest income	697	173	894	222
Other income (expense), net	(241)	(8)	(241)	(10)
Net income/(loss) before income taxes	240,135	(16,439)	207,675	(15,020)
Income tax expense	66,070	0	46,502	0
Net income/(loss)	174,065	(16,439)	161,173	(15,020)
Net income/(loss) attributable to noncontrolling interest	(833)	(803)	(1,627)	686
Net loss attributable to common stockholders of Cullinan	174,898	(15,636)	162,800	(15,706)
Comprehensive income/(loss):
Net income (loss)	174,065	(16,439)	161,173	(15,020)
Unrealized gain/(loss) on investments	(499)	(55)	(2,795)	(113)
Comprehensive income/(loss)	173,566	(16,494)	158,378	(15,133)
Comprehensive income/(loss) attributable to noncontrolling interest	(833)	(803)	(1,627)	686
Comprehensive income/(loss) attributable to Cullinan	$ 174,399	$ (15,691)	$ 160,005	$ (15,819)
Earnings (net loss) per share
Basic	$ 3.90	$ (0.36)	$ 3.65	$ (0.37)
Diluted	$ 3.77	$ (0.36)	$ 3.51	$ (0.37)
Weighted-average shares used in computing earnings (net loss) per share:
Basic	44,873	43,295	44,654	42,713
Diluted	46,381	43,295	46,389	42,713

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive (Loss)	Retained Earnings (Accumulated Deficit)	Noncontrolling Interest in Subsidiaries
Balances at Dec. 31, 2020	$ 200,314	$ 3	$ 292,348	$ (2)	$ (93,339)	$ 1,304
Balances, shares at Dec. 31, 2020		29,831,125
Equity-based compensation	3,508		3,503			5
Unrealized loss on investments	(58)			(58)
Initial public offering net of issuance costs of $22,870	264,516	$ 1	264,515
Initial public offering net of issuance costs of $22,870, shares		13,685,000
Net income (loss)	1,419				(70)	1,489
Balances at Mar. 31, 2021	469,699	$ 4	560,366	(60)	(93,409)	2,798
Balances, shares at Mar. 31, 2021		43,516,125
Balances at Dec. 31, 2020	200,314	$ 3	292,348	(2)	(93,339)	1,304
Balances, shares at Dec. 31, 2020		29,831,125
Proceeds from Issuance of Common Stock	0
Net income (loss)	(15,020)
Balances at Jun. 30, 2021	458,540	$ 4	564,705	(115)	(109,045)	2,991
Balances, shares at Jun. 30, 2021		43,526,224
Balances at Mar. 31, 2021	469,699	$ 4	560,366	(60)	(93,409)	2,798
Balances, shares at Mar. 31, 2021		43,516,125
Issuance of subsidiary preferred stock	923					923
Net issuance of common stock under equity-based compensation plans	180		180
Net issuance of common stock under equity-based compensation plans, shares		10,099
Equity-based compensation	4,165		4,159			6
Unrealized loss on investments	(55)			(55)
Issuance of subsidiary common stock	67					67
Net income (loss)	(16,439)				(15,636)	(803)
Balances at Jun. 30, 2021	458,540	$ 4	564,705	(115)	(109,045)	2,991
Balances, shares at Jun. 30, 2021		43,526,224
Balances at Dec. 31, 2021	425,374	$ 4	584,714	(838)	(158,909)	403
Balances, shares at Dec. 31, 2021		44,292,102
Issuance of subsidiary preferred stock	1,153					1,153
Net issuance of common stock under equity-based compensation plans	1,566		1,566
Net issuance of common stock under equity-based compensation plans, shares		367,924
Equity-based compensation	6,565		6,559			6
Unrealized loss on investments	(2,296)			(2,296)
Net income (loss)	(12,892)				(12,098)	(794)
Balances at Mar. 31, 2022	419,470	$ 4	592,839	(3,134)	(171,007)	768
Balances, shares at Mar. 31, 2022		44,660,026
Balances at Dec. 31, 2021	425,374	$ 4	584,714	(838)	(158,909)	403
Balances, shares at Dec. 31, 2021		44,292,102
Proceeds from Issuance of Common Stock	4,401
Net income (loss)	161,173
Balances at Jun. 30, 2022	604,618	$ 5	604,275	(3,633)	3,891	80
Balances, shares at Jun. 30, 2022		45,396,398
Balances at Mar. 31, 2022	419,470	$ 4	592,839	(3,134)	(171,007)	768
Balances, shares at Mar. 31, 2022		44,660,026
Net issuance of common stock under equity-based compensation plans	2,835	$ 1	2,834
Net issuance of common stock under equity-based compensation plans, shares		736,372
Equity-based compensation	8,608		8,602			6
Unrealized loss on investments	(499)			(499)
Issuance of subsidiary common stock	139					139
Net income (loss)	174,065				174,898	(833)
Balances at Jun. 30, 2022	$ 604,618	$ 5	$ 604,275	$ (3,633)	$ 3,891	$ 80
Balances, shares at Jun. 30, 2022		45,396,398

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) $ in Thousands	3 Months Ended
	Mar. 31, 2021 USD ($)
Statement of Stockholders' Equity [Abstract]
Initial public offering, net of issuance costs	$ 22,870

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities:
Net income (loss)	$ 161,173	$ (15,020)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Gain on sale of Cullinan Pearl	(276,785)	0
Depreciation and amortization	25	28
Equity-based compensation expense	15,173	7,673
Amortization or accretion on marketable securities	1,737	1,047
Realized loss on marketable securities	109	0
License expense in exchange for subsidiary common stock	139	67
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(1,050)	(5,199)
Accounts payable	(70)	(6,495)
Accrued expenses and other current liabilities	5,719	188
Income tax payable	46,502	0
Net cash used in operating activities	(47,328)	(17,711)
Investing activities:
Purchase of marketable securities	(93,370)	(363,252)
Proceeds from sales and maturities of marketable securities	158,933	70,932
Proceeds from sale of Cullinan Pearl, net of escrow of $5,000 and cash transferred with sale of $2,898	270,000	0
Net cash provided by (used in) investing activities	335,563	(292,320)
Financing activities:
Proceeds from initial public offering	0	267,268
Payment of deferred offering costs	0	(2,688)
Proceeds from issuance of noncontrolling interests	1,153	923
Proceeds from issuance of convertible note	2,200	0
Repayment of convertible note	(2,200)	0
Proceeds from net issuance of common stock under equity-based compensation plans	4,401	0
Net cash provided by financing activities	5,554	265,503
Net increase (decrease) in cash and cash equivalents	293,789	(44,528)
Cash and cash equivalents at beginning of period	59,774	168,198
Cash and cash equivalents at end of period	353,563	123,670
Noncash financing activities
Deferred offering costs paid in the prior year	$ 0	$ 65

CONSOLIDATED STATEMENTS OF CASH FLOWS (Parenthetical) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Statement of Cash Flows [Abstract]
net of cash transferred	$ 2,898
Net of escrow	$ 5,000

Nature of Business and Basis of Presentation

6 Months Ended

Jun. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Nature of Business and Basis of Presentation

(1)

Nature of Business and Basis of Presentation

Organization

Cullinan Oncology, Inc., together with its consolidated subsidiaries ("Cullinan" or the "Company"), is a biopharmaceutical company developing a diversified pipeline of targeted oncology therapeutic candidates across multiple modalities for cancer patients. Cullinan’s predecessor company, Cullinan Pharmaceuticals, LLC was formed in September 2016 and was subsequently renamed Cullinan Oncology, LLC (the "LLC") in November 2017. The LLC’s wholly-owned subsidiary, Cullinan Management, Inc. ("Management"), was formed in September 2016 and became the surviving entity in a reverse merger with the LLC in January 2021. In February 2021, the Company changed its name from Cullinan Management, Inc. to Cullinan Oncology, Inc.

As of June 30, 2022, the Company had three development subsidiaries ("Asset Subsidiaries"): Cullinan Amber Corp. ("Cullinan Amber"), Cullinan Florentine Corp. ("Cullinan Florentine") and Cullinan MICA Corp. ("Cullinan MICA"). As of December 31, 2021, the Company had four Asset Subsidiaries: Cullinan Amber, Cullinan Florentine, Cullinan MICA and Cullinan Pearl Corp. ("Cullinan Pearl").

The Company completed the sale of its partially-owned subsidiary, Cullinan Pearl, to Taiho Pharmaceutical Co., Ltd (“Taiho”) in June 2022. Refer to Note 3 for additional details relating to the transaction. The sale of Cullinan Pearl did not meet the criteria to be reported as a discontinued operation under the accounting principles generally accepted in the United States of America ("U.S. GAAP"). Therefore, prior period consolidated financial statements and disclosures have not been retroactively restated to reflect the impact of the sale of Cullinan Pearl.

Reorganization, Reverse Stock Split and Initial Public Offering

In January 2021, the Company completed its initial public offering ("IPO") in which it issued and sold 13,685,000 shares of its common stock, including 1,785,000 shares sold pursuant to the full exercise of the underwriters’ option to purchase additional shares, at a price to the public of $21.00 per share. The shares began trading on the Nasdaq Global Select Market on January 8, 2021 under the symbol “CGEM”. The net proceeds received by the Company from the offering were $264.5 million, after deducting underwriting discounts, commissions and other offering expenses.

Immediately prior to the effectiveness of the Company’s registration statement, the Company completed its reorganization, whereby the LLC merged with and into Management and Management was the surviving entity. Management was the registrant in the IPO.

Liquidity

The Company has incurred operating losses, with the exception of the one-time gain on the sale of Cullinan Pearl in the three and six months ended June 30, 2022, and negative cash flows from operations since its inception and expects to continue to generate operating losses for the foreseeable future. The Company’s ultimate success depends on the outcome of its research and development activities as well as the ability to commercialize the Company’s product candidates. The Company is subject to a number of risks including, but not limited to, the need to obtain adequate additional funding for the ongoing and planned clinical development of its product candidates. Due to the numerous risks and uncertainties associated with pharmaceutical products and development, the Company is unable to accurately predict the timing or amount of funds required to complete development of its product candidates, and costs could exceed the Company’s expectations for a number of reasons, including reasons beyond the Company’s control.

In June 2022, the Company completed the sale of its partially-owned subsidiary, Cullinan Pearl, to Taiho for an upfront payment of $275.0 million. Refer to Note 3 for additional details relating to the transaction.

Since inception, the Company has funded its operations primarily through the sale of equity securities and from licensing or selling the rights to its product candidates. The Company expects that its cash, cash equivalents and short-term investments of $611.0 million and long-term investments and interest receivable of $44.6 million as of June 30, 2022, will be sufficient to fund its operating expenses and capital expenditure requirements through at least the next twelve months from the date of issuance of these unaudited consolidated financial statements. Interest receivable is included in prepaid expenses and other current assets on the consolidated balance sheets and represents accrued and unpaid interest on the Company's marketable securities.

Summary of Significant Accounting Policies

6 Months Ended

Jun. 30, 2022

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

(2)

Summary of Significant Accounting Policies

Cullinan’s significant accounting policies have not changed materially from those disclosed in its annual audited consolidated financial statements and accompanying notes in the Annual Report on Form 10-K filed with the United States Securities and Exchange Commission (the “SEC”) on March 17, 2022 for the fiscal year ended December 31, 2021 (the “2021 10-K”), except for its accounting policy for leases.

Basis of Presentation

The unaudited consolidated financial statements of the Company have been prepared in conformity with U.S. GAAP and in accordance with applicable rules and regulations of the SEC for interim financial reporting and include the accounts of the Company, a wholly-owned subsidiary, and its majority-owned and controlled subsidiaries. The Company considers consolidation of entities over which control is achieved by means other than voting rights. Intercompany balances and transactions have been eliminated in consolidation. The Company operates as one segment, which is developing early-stage cancer therapeutics. In the opinion of the Company’s management, the unaudited consolidated financial statements reflect all adjustments, which are normal and recurring in nature, and necessary for fair financial statement presentation. The preparation of these unaudited consolidated financial statements and accompanying notes in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported. Actual results could differ materially from those estimates. These unaudited consolidated financial statements and accompanying notes should be read in conjunction with the Company’s annual audited consolidated financial statements and accompanying notes included in the 2021 10-K.

Leases

On January 1, 2022, the Company adopted a new standard on leases (as amended, "ASC 842"), which requires lessees to recognize a lease liability and a right-of-use asset on the balance sheet for all leases, except certain short-term leases. In connection with its implementation of ASC 842, the Company adopted a package of three practical expedients, allowing it to carry forward its previous lease classification and embedded lease evaluations and not to reassess initial direct costs as of the date of adoption. The Company also adopted a practical expedient that allows it to combine lease and non-lease components for its real estate leases.

The Company’s existing lease obligations relating to a single corporate location is subject to the new standard and resulted in operating lease liabilities and right-of-use assets ("ROU") being recorded on the Company’s consolidated balance sheets on the implementation date. The existing lease obligation is classified as an operating lease.

The below table details the balance sheet adjustments recorded on January 1, 2022 in connection with the Company’s adoption of ASC 842 (in thousands):


	December 31, 2021					January 1, 2022
	As Reported under ASC 840		ASC 842 Adjustments			As Reported Under ASC 842
Assets
Operating lease right-of-use asset	$	—	$	1,311		$	1,311
Liabilities
Current portion of operating lease liabilities	$	—	$	505		$	505
Deferred rent	$	65	$	(65	)	$	—
Noncurrent portion of operating lease liabilities	$	—	$	871		$	871

The Company determines if an arrangement is a lease at inception. A contract is or contains a lease if the contract conveys the right to control the use of an identified asset for a period of time in exchange for consideration. The Company classifies leases at the lease commencement date as operating or finance leases and records an ROU asset and a lease liability on the consolidated balance sheet for all leases with an initial lease term of greater than 12 months. Leases with an initial term of 12 months or less are not recorded in the balance sheet, and payments are recognized as expense on a straight-line basis over the lease term.

The Company enters into contracts that contain both lease and non-lease components. Non-lease components may include maintenance, utilities, and other operating costs. The Company combines the lease and non-lease components of fixed costs in its lease arrangements as a single lease component. Variable costs, such as utilities or maintenance costs, are not included in the measurement of ROU assets and lease liabilities but rather are expensed when the event determining the amount of variable consideration to be paid occurs.

Operating lease assets and liabilities are recognized at the lease commencement date based on the present value of the lease payments over the lease term using the discount rate implicit in the lease. If the discount rate is not readily determinable, the Company utilizes an estimate of its incremental borrowing rate based upon the available information at the lease commencement date. Operating lease assets are further adjusted for prepaid or accrued lease payments. Operating lease payments are expensed using the straight-line method as an operating expense over the lease term. The Company’s lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise that option.

Recently Adopted Accounting Pronouncements

In December 2019, the FASB issued ASU 2019-12, which is a new standard intended to simplify the accounting for income taxes. The Company adopted this standard on January 1, 2022. The adoption of this standard did not have a material impact on the Company's consolidated financial position and consolidated results of operations.

Sale of Cullinan Pearl and Co-Development Agreement with Taiho

6 Months Ended

Jun. 30, 2022

Debt Securities, Available-for-Sale [Abstract]

Sale of Cullinan Pearl and Co-Development Agreement with Taiho

(3)

Sale of Cullinan Pearl and Co-Development Agreement with Taiho

In June 2022, the Company sold its partially owned-subsidiary, Cullinan Pearl, which has worldwide rights to CLN-081 excluding Japan and Greater China, to Taiho for an upfront payment of $275.0 million, with an increase to the purchase price in the amount of $2.9 million for cash held by Cullinan Pearl that was transferred with the sale. As of June 30, 2022, $5.0 million of the upfront payment was held in escrow. The escrow amount was classified within prepaid expenses and other current assets on the consolidated balance sheets and will be released to the Company once the Company and Taiho finalize any post-sale net working capital adjustment, which is not expected to be material. Pursuant to the share purchase agreement with Taiho, the Company is also eligible to receive an additional $130.0 million tied to epidermal growth factor receptor exon20 non-small-cell lung cancer regulatory milestones.

The Company concluded the transaction was a sale of non-financial assets, which comprised mainly of intellectual property rights and related intangible assets, and that it transferred control of the non-financial assets at the closing of the sale. The Company recognized a gain on sale of Cullinan Pearl of $276.8 million within income from operations in its consolidated statement of operations and other comprehensive income (loss) for the three and six months ended June 30, 2022. The table below sets forth the book value of the Cullinan Pearl assets and liabilities sold along with the calculation of the gain on sale based on the cash consideration received.


	(in thousands)
Book value of assets sold
Cash	$	2,898
Prepaid expenses and other current assets		619
Amounts attributable to assets sold		3,517
Book value of liabilities sold
Accrued expenses and other current liabilities		2,404
Amounts attributable to liabilities sold		2,404
Total identifiable net assets sold		1,113
Upfront consideration, inclusive of $5,000 escrow and cash transferred of $2,898		277,898
Gain on sale of Cullinan Pearl	$	276,785

During the six months ended June 30, 2022, Cullinan Pearl issued $2.2 million of convertible notes to an affiliate of Taiho. The Company repaid these convertible notes at the closing of the Cullinan Pearl sale.

Co-Development Agreement with Taiho

In June 2022, concurrently with the closing of the sale of Cullinan Pearl, the Company entered into a co-development agreement with an affiliate of Taiho, pursuant to which the Company will collaborate to develop CLN-081 and will retain the option to co-commercialize CLN-081 in the U.S. Taiho has the exclusive right to commercialize CLN-081 in territories outside the U.S., excluding Greater China. Development costs for CLN-081 incurred after the sale of Cullinan Pearl shall be shared equally between Taiho and the Company with each party receiving 50% of any future pre-tax profits from potential U.S. sales of CLN-081.

The Company concluded that the co-development agreement with Taiho is a collaborative arrangement because the Company is an active participant in the development of CLN-081. Payments made to or received from Taiho for CLN-081 development activities after the sale are recorded within research and development expenses.

Financial Instruments

6 Months Ended

Jun. 30, 2022

Financial Instruments Pledged as Collateral [Abstract]

Financial Instruments

(4)

Financial Instruments

Investments

The Company recognized its short-term and long-term investments by security type at June 30, 2022 as follows:


	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
	(in thousands)
Short-term investments
Corporate notes	$	132,863	$	—	$	(1,783	)	$	131,080
Asset-backed securities		3,023		—		(42	)		2,981
Commercial paper		62,047		—		(132	)		61,915
U.S. government notes		62,139		—		(683	)		61,456
Total short-term investments		260,072		—		(2,640	)		257,432
Long-term investments
Corporate notes		44,175		—		(993	)		43,182
Total long-term investments		44,175		—		(993	)		43,182
Total investments	$	304,247	$	—	$	(3,633	)	$	300,614

The Company recognized its short-term and long-term investments by security type at December 31, 2021 as follows:


	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
	(in thousands)
Short-term investments
Corporate notes	$	98,642	$	—	$	(95	)	$	98,547
Commercial paper		114,174		—		(27	)		114,147
U.S. government notes		18,033		—		(35	)		17,998
Total short-term investments		230,849		—		(157	)		230,692
Long-term investments
Corporate notes		117,868		—		(596	)		117,272
Asset-backed securities		3,044		—		(8	)		3,036
U.S. government notes		20,166		—		(77	)		20,089
Total long-term investments		141,078		—		(681	)		140,397
Total investments	$	371,927	$	—	$	(838	)	$	371,089

Fair Value of Financial Instruments

The following table sets forth the fair value of the Company’s financial assets that were measured at fair value on a recurring basis as of June 30, 2022:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Cash and cash equivalents
Cash	$	293,193	$	—	$	—	$	293,193
Money market funds		60,370		—		—		60,370
Total cash and cash equivalents		353,563		—		—		353,563
Short-term investments
Corporate notes		—		131,080		—		131,080
Asset-backed securities		—		2,981		—		2,981
Commercial paper		—		61,915		—		61,915
U.S. government notes		—		61,456		—		61,456
Total short-term investments		—		257,432		—		257,432
Long-term investments
Corporate notes		—		43,182		—		43,182
U.S. government notes		—		—		—		—
Total long-term investments		—		43,182		—		43,182
Total cash, cash equivalents and investments	$	353,563	$	300,614	$	—	$	654,177

The following table sets forth the fair value of the Company’s financial assets that were measured at fair value on a recurring basis as of December 31, 2021:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Cash and cash equivalents
Cash	$	35,925	$	—	$	—	$	35,925
Money market funds		23,849		—		—		23,849
Total cash and cash equivalents		59,774		—		—		59,774
Short-term investments
Corporate notes		—		98,547		—		98,547
Commercial paper		—		114,147		—		114,147
U.S. government notes		—		17,998		—		17,998
Total short-term investments		—		230,692		—		230,692
Long-term investments
Corporate notes		—		117,272		—		117,272
Asset-backed securities		—		3,036		—		3,036
U.S. government notes		—		20,089		—		20,089
Total long-term investments		—		140,397		—		140,397
Total cash, cash equivalents and investments	$	59,774	$	371,089	$	—	$	430,863

Prepaid expenses and other current assets, accounts payable and accrued expenses and other current liabilities were carried at cost, which management believes approximated fair value due to their short-term nature.

Accrued Expenses and Other Current Liabilities

6 Months Ended

Jun. 30, 2022

Accrued Expenses And Other Current Liabilities [Abstract]

Accrued Expenses and Other Current Liabilities

(5)

Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following:


	June 30, 2022		December 31, 2021
	(in thousands)
Accrued research and development expenses	$	8,337	$	5,028
Accrued bonus		2,436		2,576
Other current liabilities		1,128		973
	$	11,901	$	8,577

License and Collaboration Agreements

6 Months Ended

Jun. 30, 2022

License And Collaboration Agreements [Abstract]

License and Collaboration Agreements

(6)

License and Collaboration Agreements

For the three months ended June 30, 2022 and 2021, the Company recorded $0.2 million and $0.1 million, respectively, within research and development expenses relating to the license agreement ("MIT License Agreement") with the Massachusetts Institute of Technology ("MIT") through Cullinan Amber.

For the six months ended June 30, 2022, the Company recorded $0.5 million in research and development expenses relating to the collaboration agreement with Adimab where the Company exercised its option to exploit Adimab's antibodies and $0.2 million within research and development expenses relating to the MIT License Agreement. For the six months ended June 30, 2021, the Company recorded $3.0 million within research and development expenses under a revenue sharing agreement with Taiho upon receipt of an upfront payment for licensing the Greater China rights for CLN-081 to Zai Lab (Shanghai) Co., Ltd. and $0.1 million within research and development expenses relating to the MIT License Agreement.

Common Stock and Noncontrolling Interest in Subsidiaries

6 Months Ended

Jun. 30, 2022

Common Stock And Noncontrolling Interest In Subsidiaries [Abstract]

Common Stock and Noncontrolling Interest in Subsidiaries

(7)

Common Stock and Noncontrolling Interests in Subsidiaries

Common Stock

Each share of common stock entitles the holder to one vote and to receive dividends when and if declared by the board of directors of the Company. No dividends have been declared through June 30, 2022.

Noncontrolling Interests in Subsidiaries

Certain subsidiaries issue common stock in connection with licensing agreements and to employees, directors and consultants pursuant to subsidiary equity incentive plans. The holders of subsidiary common stock are entitled to one vote per share. The holders of subsidiary common stock are entitled to receive dividends when and if declared by the subsidiaries’ board of directors and distributions in either case only after the payment of all preferential amounts required to be paid to the holders of shares of preferred stock of the respective subsidiary.

Cullinan Amber

In June 2021, Cullinan Amber issued 3.0 million shares of its Series A Preferred Stock to the Company for gross proceeds of $3.0 million and 0.2 million shares of its common stock to MIT in exchange for no additional consideration, pursuant to the MIT License Agreement.

In June 2022, Cullinan Amber issued 6.0 million shares of its Series A Preferred Stock to the Company for gross proceeds of $6.0 million and 0.3 million shares of its common stock to MIT in exchange for no additional consideration, pursuant to the MIT License Agreement.

As of June 30, 2022, the Company holds common shares and Series A Preferred Stock that represent 93.5% of Cullinan Amber's outstanding equity. As of June 30, 2022, noncontrolling interests collectively own common shares representing 6.5% of the fully-diluted shares outstanding of Cullinan Amber.

Under the hypothetical liquidation book value ("HLBV") method, $0.1 million of losses were attributed to the noncontrolling interests of Cullinan Amber for each of the three and six months ended June 30, 2022. For each of the three and six months ended June 30, 2021, less than $0.1 million of losses were attributed to the noncontrolling interests of Cullinan Amber.

Cullinan Florentine

In July 2021, Cullinan Florentine issued 7.5 million shares of Series B Preferred Stock to the Company for gross proceeds of $8.1 million.

As of June 30, 2022, the Company holds common shares, Series A Preferred Stock and Series B preferred stock that represent 94.8% of Cullinan Florentine's outstanding equity. As of June 30, 2022, noncontrolling interests collectively hold common shares that represent 5.2% of Cullinan Florentine's outstanding equity.

The Company did not allocate any losses to the noncontrolling interests of Cullinan Florentine for each of the three and six months ended June 30, 2022 and 2021.

Cullinan MICA

In June 2021, the Company purchased 5.4 million shares of Cullinan MICA’s Series A Senior Preferred Stock for $7.1 million, and certain other existing investors purchased 0.7 million shares of Cullinan MICA’s Series A Senior Preferred Stock for $0.9 million.

In March 2022, the Company purchased 6.7 million shares of Cullinan MICA’s Series A Senior Preferred Stock for $8.8 million, and certain other existing investors purchased 0.9 million shares of Cullinan MICA’s Series A Senior Preferred Stock for $1.2 million.

As of June 30, 2022, the Company holds common shares and Series A Senior Preferred Stock that represent 53.5% of Cullinan MICA's outstanding equity. As of June 30, 2022, noncontrolling interests hold common shares, Series A Junior Preferred Stock and Series A Senior Preferred Stock that represent 46.5% of Cullinan MICA's outstanding equity.

Under the HLBV method, $0.7 million and $1.1 million of losses were attributed to the noncontrolling interests of Cullinan MICA for the three and six months ended June 30, 2022, respectively. Under the HLBV method, $0.2 million and $0.5 million of losses were attributed to the noncontrolling interests of Cullinan MICA for the three and six months ended June 30, 2021, respectively.

Cullinan Pearl Corp.

In June 2022, the Company sold its partially-owned subsidiary, Cullinan Pearl, to Taiho. Refer to Note 3 for additional details relating to the transaction.

Prior to the sale, the Company accounted for the noncontrolling interest using the HLBV method. The Company did not allocate any losses to the noncontrolling interests of Cullinan Pearl for the three months ended June 30, 2022. The Company allocated $0.3 million of losses to noncontrolling interests for the six months ended June 30, 2022. Under the HLBV method, $0.5 million of losses and $1.2 million of income were attributed to the noncontrolling interests of Cullinan Pearl for the three and six months ended June 30, 2021, respectively.

Equity-Based Compensation

6 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Equity-Based Compensation

(8)

Equity-Based Compensation

Market-based restricted stock units ("RSUs")

In June 2022, the Company entered into an agreement to grant market-based RSUs to its Chief Executive Officer. For equity awards with a market-based vesting condition, the Company recognizes compensation expense over the requisite service period using the fair value at the grant date. The number of shares issuable, if any, when a market-based RSU award vests, will depend on the degree of achievement of the corporate stock price metrics within the performance period of the award.

The Company measures the fair value of market-based RSUs on the date of grant using a Monte Carlo simulation model. The Monte Carlo simulation requires the input of assumptions, including the Company's stock price, the volatility of its stock price, remaining term in years, expected dividend yield and risk-free rate. The Company used its own trading history to calculate the expected volatility of the market-based RSUs granted. The risk-free interest rate is determined by reference to implied yields available from U.S. Treasury securities with a remaining term equal to the expected term assumed at the grant date.

The following table details the assumptions used in the Monte Carlo simulation model used to estimate the fair value of the market-based RSUs granted:


	Three Months Ended June 30, 2022
Stock price	$	12.98
Volatility		82.5	%
Remaining term (years)		2.7
Risk-free rate		2.9	%
Expected dividend yield		0.0	%

The Company recorded equity-based compensation in the following expense categories in the consolidated statements of operations and comprehensive income (loss):


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
	(in thousands)
Research and development	$	4,379	$	2,293	$	7,039	$	3,862
General and administrative		4,229		1,872		8,134		3,811
Total equity-based compensation	$	8,608	$	4,165	$	15,173	$	7,673

Related Party Transactions

6 Months Ended

Jun. 30, 2022

Related Party Transactions

(9)

Related Party Transactions

Royalty Transfer Agreements

Each of the Asset Subsidiaries is party to royalty transfer agreements with MPM Oncology Charitable Foundation, Inc. and UBS Optimus Foundation (together, the "Foundations"). Under each of these respective agreements, each Foundation is entitled to receive a royalty equal to 0.5% (1.0% in aggregate) of all global net sales of any products developed by the applicable subsidiary, subject to limitations after patent expirations and on intellectual property developed after a change of control. The Company has deemed these royalty transfer agreements to be freestanding financial instruments that should be accounted for at fair value. The Company has concluded that these instruments had no value at the inception of the agreements.

Given the early-stage nature of the underlying technologies and inherent technical, regulatory and competitive risks associated with achieving approval and commercialization, the Company ascribed no value to the royalty transfer agreements as of June 30, 2022 and December 31, 2021. The Company currently does not have any applicable net sales from its products and as a result, has not paid or incurred any royalties under these agreements as of June 30, 2022. The Company will monitor these instruments for changes in fair value at each reporting date.

Income Taxes

6 Months Ended

Jun. 30, 2022

Income Tax Disclosure [Abstract]

Income Taxes

(10)

Income Taxes

During the three months and six months ended June 30, 2022, the Company recorded an income tax provision of $66.1 million and $46.5 million, respectively. The tax provision recorded for the period ended June 30, 2022 was driven by the expected tax from the gain on sale of Cullinan Pearl, partially offset by the release of valuation allowance for the expected utilization of current year and certain historical tax attributes against the gain from the sale. Refer to Note 3 for additional details on this transaction. The Company did not record an income tax benefit or expense for the three and six months ended June 30, 2021.

The Company has evaluated the positive and negative evidence bearing upon its ability to realize its deferred tax assets, which primarily consist of net operating loss carryforwards. The Company has considered its history of cumulative net losses, estimated future taxable income and prudent and feasible tax planning strategies and has concluded that it is more likely than not that the Company will not realize the benefits of its deferred tax assets, outside of the tax losses that will be utilized against the gain on sale of Cullinan Pearl. As a result, as of June 30, 2022, the Company has maintained a full valuation allowance against its remaining net deferred tax assets.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 21
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32857-109319

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SAB Topic 11.C)
-URI https://asc.fasb.org/extlink&oid=122134291&loc=d3e330215-122817

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 17
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32809-109319

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 6.I.5.Q1)
-URI https://asc.fasb.org/extlink&oid=122134291&loc=d3e330036-122817

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 14
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32705-109319

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 270
-Section 50
-Paragraph 1
-URI https://asc.fasb.org/extlink&oid=6424409&loc=d3e44925-109338

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-URI https://asc.fasb.org/topic&trid=2144680

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 30
-Section 50
-Paragraph 2
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=6424122&loc=d3e41874-109331

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h)(2))
-URI https://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

+ Details

Commitments and Contingencies

6 Months Ended

Jun. 30, 2022

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

(11)

Commitment and Contingencies

The Company enters into contracts in the normal course of business with contract research organizations, contract manufacturing organizations, and other third parties for preclinical research studies, clinical trials and testing and manufacturing services. These contracts do not contain minimum purchase commitments and are cancelable upon prior written notice. Payments due upon cancellation consist only of payments for services provided or expenses incurred, including noncancelable obligations of service providers, up to the date of cancellation.

Indemnification agreements

In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessor, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its board of directors and executive officers that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in certain cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company is not aware of any indemnification arrangements that could have a material effect on its financial position, results of operations or cash flows, and it has not accrued any liabilities related to such obligations in its consolidated financial statements as of June 30, 2022 and December 31, 2021.

Legal proceedings

The Company is not currently party to or aware of any material legal proceedings. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company expenses as incurred the costs related to such legal proceedings.

Leases

6 Months Ended

Jun. 30, 2022

Leases [Abstract]

Leases

(12)

Leases

The Company has an operating lease for 7,531 rentable square feet of office space in Cambridge, Massachusetts, which commenced on February 1, 2018 and expires on June 30, 2024. Lease expense consisted of operating lease costs of $0.1 million and $0.3 million for the three and six months ended June 30, 2022, respectively. Rent expense under the prior lease accounting standard was $0.2 million and $0.3 million for the three and six months ended June 30, 2021, respectively.

The following table summarizes supplemental cash flow information (in thousands):


	Six Months Ended June 30, 2022
Cash paid for amounts included in measurement of lease liabilities:
Operating cash flows from operating leases	$	303
ROU asset obtained in exchange for an operating lease liability	$	1,311

The following table summarizes the Company’s future minimum lease payments and reconciliation of lease liabilities (in thousands):


	June 30, 2022
Remainder of 2022	$	305
2023		618
2024		313
Total future minimum lease payments		1,236
Less: imputed interest		(107	)
Total lease liabilities at present value	$	1,129
Lease liabilities, current	$	533
Lease liabilities, non-current	$	596

The following table summarizes lease term and discount rate:


	June 30, 2022
Weighted-average remaining lease term (years)		2.0
Weighted-average discount rate		9.5	%

As the Company’s operating leases did not provide an implicit rate, the Company used its incremental borrowing rate based on the information available in determining the present value of lease payments. The Company’s incremental borrowing rate was based on the term of the lease, the economic environment and reflects the rate the Company would have had to pay to borrow on a secured basis.

Earnings per Share

6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Earnings per Share

(13)

Earnings per Share

The following table sets forth the calculation of basic and diluted earnings (net loss) per share:


	Three Months Ended June 30,					Six Months Ended June 30,
	2022		2021			2022		2021
	(in thousands, except per share data)
Numerator:
Net income (loss) attributable to common stockholders of Cullinan	$	174,898	$	(15,636	)	$	162,800	$	(15,706	)
Denominator:
Weighted-average common stock outstanding - basic		44,873		43,295			44,654		42,713
Dilutive effect of common stock issuable from assumed exercise of equity awards		1,508		—			1,735		—
Weighted-average common stock outstanding - diluted		46,381		43,295			46,389		42,713
Earnings (net loss) per share:
Basic	$	3.90	$	(0.36	)	$	3.65	$	(0.37	)
Diluted	$	3.77	$	(0.36	)	$	3.51	$	(0.37	)

The Company used the treasury stock method to determine the number of dilutive shares. The following table sets forth potential common shares that were excluded from the computation of the diluted net income (loss) per share for the periods presented because their effect would have been anti-dilutive:


	As of June 30,
	2022		2021
	(in thousands)
Restricted stock units		—		180
Stock options		6,250		6,951
Total		6,250		7,131

Summary of Significant Accounting Policies (Policies)

6 Months Ended

Jun. 30, 2022

Accounting Policies [Abstract]

Basis of Presentation

Leases

The below table details the balance sheet adjustments recorded on January 1, 2022 in connection with the Company’s adoption of ASC 842 (in thousands):


	December 31, 2021					January 1, 2022
	As Reported under ASC 840		ASC 842 Adjustments			As Reported Under ASC 842
Assets
Operating lease right-of-use asset	$	—	$	1,311		$	1,311
Liabilities
Current portion of operating lease liabilities	$	—	$	505		$	505
Deferred rent	$	65	$	(65	)	$	—
Noncurrent portion of operating lease liabilities	$	—	$	871		$	871

Recently Adopted Accounting Pronouncements

Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2022

Accounting Policies [Abstract]

Supplemental Balance Sheet Information Related to Operating Leases

The below table details the balance sheet adjustments recorded on January 1, 2022 in connection with the Company’s adoption of ASC 842 (in thousands):


	December 31, 2021					January 1, 2022
	As Reported under ASC 840		ASC 842 Adjustments			As Reported Under ASC 842
Assets
Operating lease right-of-use asset	$	—	$	1,311		$	1,311
Liabilities
Current portion of operating lease liabilities	$	—	$	505		$	505
Deferred rent	$	65	$	(65	)	$	—
Noncurrent portion of operating lease liabilities	$	—	$	871		$	871

Sale of Cullinan Pearl and Co-Development Agreement with Taiho (Tables)

6 Months Ended

Jun. 30, 2022

Debt Securities, Available-for-Sale [Abstract]

Schedule of cash consideration received

The table below sets forth the book value of the Cullinan Pearl assets and liabilities sold along with the calculation of the gain on sale based on the cash consideration received.


	(in thousands)
Book value of assets sold
Cash	$	2,898
Prepaid expenses and other current assets		619
Amounts attributable to assets sold		3,517
Book value of liabilities sold
Accrued expenses and other current liabilities		2,404
Amounts attributable to liabilities sold		2,404
Total identifiable net assets sold		1,113
Upfront consideration, inclusive of $5,000 escrow and cash transferred of $2,898		277,898
Gain on sale of Cullinan Pearl	$	276,785

Financial Instruments (Tables)

6 Months Ended

Jun. 30, 2022

Financial Instruments Pledged as Collateral [Abstract]

Schedule of Short-term and Long-term Investment Marketable Securities by Security Type

The Company recognized its short-term and long-term investments by security type at June 30, 2022 as follows:


	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
	(in thousands)
Short-term investments
Corporate notes	$	132,863	$	—	$	(1,783	)	$	131,080
Asset-backed securities		3,023		—		(42	)		2,981
Commercial paper		62,047		—		(132	)		61,915
U.S. government notes		62,139		—		(683	)		61,456
Total short-term investments		260,072		—		(2,640	)		257,432
Long-term investments
Corporate notes		44,175		—		(993	)		43,182
Total long-term investments		44,175		—		(993	)		43,182
Total investments	$	304,247	$	—	$	(3,633	)	$	300,614

The Company recognized its short-term and long-term investments by security type at December 31, 2021 as follows:


	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Estimated Fair Value
	(in thousands)
Short-term investments
Corporate notes	$	98,642	$	—	$	(95	)	$	98,547
Commercial paper		114,174		—		(27	)		114,147
U.S. government notes		18,033		—		(35	)		17,998
Total short-term investments		230,849		—		(157	)		230,692
Long-term investments
Corporate notes		117,868		—		(596	)		117,272
Asset-backed securities		3,044		—		(8	)		3,036
U.S. government notes		20,166		—		(77	)		20,089
Total long-term investments		141,078		—		(681	)		140,397
Total investments	$	371,927	$	—	$	(838	)	$	371,089

Summary of Fair Value of Financial Assets Measured at Fair Value on a Recurring Basis

The following table sets forth the fair value of the Company’s financial assets that were measured at fair value on a recurring basis as of June 30, 2022:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Cash and cash equivalents
Cash	$	293,193	$	—	$	—	$	293,193
Money market funds		60,370		—		—		60,370
Total cash and cash equivalents		353,563		—		—		353,563
Short-term investments
Corporate notes		—		131,080		—		131,080
Asset-backed securities		—		2,981		—		2,981
Commercial paper		—		61,915		—		61,915
U.S. government notes		—		61,456		—		61,456
Total short-term investments		—		257,432		—		257,432
Long-term investments
Corporate notes		—		43,182		—		43,182
U.S. government notes		—		—		—		—
Total long-term investments		—		43,182		—		43,182
Total cash, cash equivalents and investments	$	353,563	$	300,614	$	—	$	654,177

The following table sets forth the fair value of the Company’s financial assets that were measured at fair value on a recurring basis as of December 31, 2021:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Cash and cash equivalents
Cash	$	35,925	$	—	$	—	$	35,925
Money market funds		23,849		—		—		23,849
Total cash and cash equivalents		59,774		—		—		59,774
Short-term investments
Corporate notes		—		98,547		—		98,547
Commercial paper		—		114,147		—		114,147
U.S. government notes		—		17,998		—		17,998
Total short-term investments		—		230,692		—		230,692
Long-term investments
Corporate notes		—		117,272		—		117,272
Asset-backed securities		—		3,036		—		3,036
U.S. government notes		—		20,089		—		20,089
Total long-term investments		—		140,397		—		140,397
Total cash, cash equivalents and investments	$	59,774	$	371,089	$	—	$	430,863

- Definition

Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances.

+ References + Details

Accrued Expenses and Other Current Liabilities (Tables)

6 Months Ended

Jun. 30, 2022

Accrued Expenses And Other Current Liabilities [Abstract]

Summary of Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following:


	June 30, 2022		December 31, 2021
	(in thousands)
Accrued research and development expenses	$	8,337	$	5,028
Accrued bonus		2,436		2,576
Other current liabilities		1,128		973
	$	11,901	$	8,577

Equity-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Schedule of Assumptions Used to Estimate Fair value of Market-Based RSUs Granted

The following table details the assumptions used in the Monte Carlo simulation model used to estimate the fair value of the market-based RSUs granted:


	Three Months Ended June 30, 2022
Stock price	$	12.98
Volatility		82.5	%
Remaining term (years)		2.7
Risk-free rate		2.9	%
Expected dividend yield		0.0	%

Schedule of Equity-based Compensation Expense Categories In Consolidated Statements of Operations and Comprehensive Income (Loss)

The Company recorded equity-based compensation in the following expense categories in the consolidated statements of operations and comprehensive income (loss):


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
	(in thousands)
Research and development	$	4,379	$	2,293	$	7,039	$	3,862
General and administrative		4,229		1,872		8,134		3,811
Total equity-based compensation	$	8,608	$	4,165	$	15,173	$	7,673

Leases (Tables)

6 Months Ended

Jun. 30, 2022

Leases [Abstract]

Supplemental Cash Flow Information Relating to Leases

The following table summarizes supplemental cash flow information (in thousands):


	Six Months Ended June 30, 2022
Cash paid for amounts included in measurement of lease liabilities:
Operating cash flows from operating leases	$	303
ROU asset obtained in exchange for an operating lease liability	$	1,311

Summarizes of future minimum lease payments

The following table summarizes the Company’s future minimum lease payments and reconciliation of lease liabilities (in thousands):


	June 30, 2022
Remainder of 2022	$	305
2023		618
2024		313
Total future minimum lease payments		1,236
Less: imputed interest		(107	)
Total lease liabilities at present value	$	1,129
Lease liabilities, current	$	533
Lease liabilities, non-current	$	596

Summarizes Lease Term and Discount Rate

The following table summarizes lease term and discount rate:


	June 30, 2022
Weighted-average remaining lease term (years)		2.0
Weighted-average discount rate		9.5	%

Earnings per Share (Tables)

6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Summary of Calculation of Basic and Diluted Net Loss Per Share

The following table sets forth the calculation of basic and diluted earnings (net loss) per share:


	Three Months Ended June 30,					Six Months Ended June 30,
	2022		2021			2022		2021
	(in thousands, except per share data)
Numerator:
Net income (loss) attributable to common stockholders of Cullinan	$	174,898	$	(15,636	)	$	162,800	$	(15,706	)
Denominator:
Weighted-average common stock outstanding - basic		44,873		43,295			44,654		42,713
Dilutive effect of common stock issuable from assumed exercise of equity awards		1,508		—			1,735		—
Weighted-average common stock outstanding - diluted		46,381		43,295			46,389		42,713
Earnings (net loss) per share:
Basic	$	3.90	$	(0.36	)	$	3.65	$	(0.37	)
Diluted	$	3.77	$	(0.36	)	$	3.51	$	(0.37	)

Summary of Outstanding Equity Instruments Excluded from Computation of Diluted Net Income (Loss) Per Share

The following table sets forth potential common shares that were excluded from the computation of the diluted net income (loss) per share for the periods presented because their effect would have been anti-dilutive:


	As of June 30,
	2022		2021
	(in thousands)
Restricted stock units		—		180
Stock options		6,250		6,951
Total		6,250		7,131

Nature of Business and Basis of Presentation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	6 Months Ended
	Jan. 31, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Nature Of Business And Basis Of Presentation [Line Items]
Proceeds from initial public offering	$ 264,500	$ 0	$ 267,268
Long-term investments and interest receivables		44,600
Retained earnings (accumulated deficit)		3,891		$ (158,909)
Up-front payment		275,000
Cash, cash equivalents, short-term investments and long-term investments		$ 611,000
IPO
Nature Of Business And Basis Of Presentation [Line Items]
Common stock shares issued and sold	13,685,000
Stock, price per Share	$ 21.00
Underwriters' Option
Nature Of Business And Basis Of Presentation [Line Items]
Common stock shares issued and sold	1,785,000

Summary of Significant Accounting Policies - Additional Information (Details)	6 Months Ended
	Jun. 30, 2022 Segment
Accounting Policies [Abstract]
Number of operating segments	1
Operating Lease Term	12 months

Summary of Significant Accounting Policies - Supplemental Balance Sheet Information Related to Operating Leases (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Jan. 01, 2022	Dec. 31, 2021
Operating lease right-of-use assets	$ 1,074		$ 0
Operating lease liabilities, current	533		0
Deferred rent	0		65
Noncurrent portion of operating lease liabilities	596		0
As Reported
Operating lease right-of-use assets		$ 1,311	0
Operating lease liabilities, current		505	0
Deferred rent		0	65
Noncurrent portion of operating lease liabilities		$ 871	$ 0
Adjustment
Operating lease right-of-use assets	1,311
Operating lease liabilities, current	505
Deferred rent	(65)
Noncurrent portion of operating lease liabilities	$ 871

Reorganization and Reverse Stock Split - Summary of LLC Units Previously Reported as Redeemable Preferred Units or Temporary Equity Converted Reclassified to Equity (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2021	Jun. 30, 2021	Mar. 31, 2021	Dec. 31, 2020
Stockholders' Equity (Members' Deficit)
Common Stock	$ 5		$ 4
Additional paid-in capital	604,275		584,714
Accumulated other comprehensive loss	(3,633)		(838)
Retained earnings (accumulated deficit)	3,891		(158,909)
Total Cullinan Stockholders' Equity (Members' Deficit)	604,538		424,971
Non-controlling interests in subsidiaries	80		403
Total Stockholders' Equity (Members' Deficit)	$ 604,618	$ 419,470	$ 425,374	$ 458,540	$ 469,699	$ 200,314

- Definition

Accumulated change in equity from transactions and other events and circumstances from non-owner sources, net of tax effect, at period end. Excludes Net Income (Loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners. Includes foreign currency translation items, certain pension adjustments, unrealized gains and losses on certain investments in debt and equity securities, other than temporary impairment (OTTI) losses related to factors other than credit losses on available-for-sale and held-to-maturity debt securities that an entity does not intend to sell and it is not more likely than not that the entity will be required to sell before recovery of the amortized cost basis, as well as changes in the fair value of derivatives related to the effective portion of a designated cash flow hedge.

+ References + Details

- Definition

Total of all stockholders' equity (deficit) items, net of receivables from officers, directors, owners, and affiliates of the entity which is directly or indirectly attributable to that ownership interest in subsidiary equity which is not attributable to the parent (that is, noncontrolling interest, previously referred to as minority interest).

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Total of all stockholders' equity (deficit) items, net of receivables from officers, directors, owners, and affiliates of the entity which are attributable to the parent. The amount of the economic entity's stockholders' equity attributable to the parent excludes the amount of stockholders' equity which is allocable to that ownership interest in subsidiary equity which is not attributable to the parent (noncontrolling interest, minority interest). This excludes temporary equity and is sometimes called permanent equity.

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Amount of stockholders' equity (deficit), net of receivables from officers, directors, owners, and affiliates of the entity, attributable to both the parent and noncontrolling interests. Amount excludes temporary equity. Alternate caption for the concept is permanent equity.

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+ Details

Sale of Cullinan Pearl and Co-Development Agreement with Taiho - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Defined Benefit Plan Disclosure [Line Items]
Repayment of convertible notes				$ 2,200	$ 0
net of cash transferred				2,898
Gain on sale of Cullinan Pearl		$ (276,785)	$ 0	(276,785)	$ 0
Payment held in escrow				5,000
Pearl - Taiho
Defined Benefit Plan Disclosure [Line Items]
Repayment of convertible notes				2,200
net of cash transferred	$ 2,900
Additional receive payments from the party	130,000
Receive upfront payment from party	$ 275,000
Gain on sale of Cullinan Pearl		$ (276,800)		(276,800)
Payment held in escrow				$ 5,000
Percentage of profits from potential sales	50.00%

Sale of Cullinan Pearl and Co-Development Agreement with Taiho - Schedule of cash consideration received (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Book Value of Asset Sold [Abstract]
Cash	$ 2,898
Cash	2,898
Prepaid expenses and other current assets	619
Amounts attributable to assets sold	3,517
Book Value Of Liability Sold [Abstract]
Accrued expenses and other current liabilities	2,404
Amounts attributable to liabilities assumed	2,404
Total identifiable net assets sold	1,113
Upfront consideration, inclusive of $5,000 escrow and cash transferred of $2,898	277,898
Gain on sale of Cullinan Pearl	$ 276,785

Sale of Cullinan Pearl and Co-Development Agreement with Taiho - Parenthetical (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Debt Securities, Available-for-Sale [Abstract]
Payment held in escrow	$ 5,000
Upfront consideration, cash transferred	$ 2,898

Financial Instruments - Schedule of Short-term and Long-term Investment Marketable Securities by Security Type (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	$ 304,247	$ 371,927
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(3,633)	(838)
Estimated Fair Value	300,614	371,089
Long Term Investment
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	44,175	141,078
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(993)	(681)
Estimated Fair Value	43,182	140,397
Long Term Investment \| U.S. Government Notes
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost		20,166
Gross Unrealized Gains		0
Gross Unrealized Losses		(77)
Estimated Fair Value		20,089
Corporate Note Securities \| Long Term Investment
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	44,175	117,868
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(993)	(596)
Estimated Fair Value	43,182	117,272
Asset-backed Securities \| Long Term Investment
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost		3,044
Gross Unrealized Gains		0
Gross Unrealized Losses		(8)
Estimated Fair Value		3,036
Short Term Investments
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	260,072	230,849
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(2,640)	(157)
Estimated Fair Value	257,432	230,692
Short Term Investments \| U.S. Government Notes
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	62,139	18,033
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(683)	(35)
Estimated Fair Value	61,456	17,998
Short Term Investments \| Corporate Note Securities
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	132,863	98,642
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(1,783)	(95)
Estimated Fair Value	131,080	98,547
Short Term Investments \| Asset-backed Securities
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	3,023
Gross Unrealized Gains	0
Gross Unrealized Losses	(42)
Estimated Fair Value	2,981
Short Term Investments \| Commercial Paper
Available For Sale Securities Fair Value To Amortized Cost Basis [Line Items]
Amortized Cost	62,047	114,174
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(132)	(27)
Estimated Fair Value	$ 61,915	$ 114,147

Accrued Expenses and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Accounts Payable and Accrued Liabilities, Current [Abstract]
Research and development expenses	$ 8,337	$ 5,028
Bonus	2,436	2,576
Other current liabilities	1,128	973
Accrued expenses and other current liabilities	$ 11,901	$ 8,577

License and Collaboration Agreements - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
License And Collaboration Agreements [Line Items]
Research and development costs	$ 26,411	$ 11,778	$ 50,947	$ 24,193
Pearl - Taiho \| Collaboration and License Agreements
License And Collaboration Agreements [Line Items]
Research and development costs				3,000
Adimab \| Collaboration and License Agreements
License And Collaboration Agreements [Line Items]
Research and development costs			500
MIT \| Collaboration and License Agreements
License And Collaboration Agreements [Line Items]
Research and development costs	$ 200	$ 100	$ 200	$ 100

Common Stock and Noncontrolling Interest in Subsidiaries - Additional Information (Details) - USD ($)	1 Months Ended			3 Months Ended			6 Months Ended
	Mar. 31, 2022	Jul. 31, 2021	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Dividends declared				$ 0			$ 0
Common stock, voting rights							Each share of common stock entitles the holder to one vote and to receive dividends when and if declared by the board of directors of the Company.
Shares sold/issued				45,396,398			45,396,398		44,292,102
Losses attributed to noncontrolling interests				$ (833,000)	$ (803,000)		$ (1,627,000)	$ 686,000
Common Stock
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Additional shares issued						13,685,000
Noncontrolling Interest in Subsidiaries \| HLBV
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Losses attributed to noncontrolling interests				$ 100,000			100,000
License Agreement between Amber and Massachusetts Institute of Technology \| Common Stock
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Shares sold/issued			200,000		200,000			200,000
Additional consideration received							$ 0	$ 0
Maximum \| Noncontrolling Interest in Subsidiaries \| HLBV
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Losses attributed to noncontrolling interests					$ 100,000			$ 100,000
Cullinan Amber Corp \| Common Stock
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Shares issued				300,000			300,000
Cullinan Amber Corp \| Series A Preferred Stock
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Shares issued			3,000,000.0	6,000,000.0	3,000,000.0		6,000,000.0	3,000,000.0
Gross proceeds							$ 6,000,000.0	$ 3,000,000.0
Percentage of share purchased as part of asset acquisition							93.50%
Ownership interest percentage							6.50%
Cullinan Florentine Corp \| HLBV
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Losses attributed to noncontrolling interests				$ 0	$ 0		$ 0	0
Cullinan Florentine Corp \| Series A Preferred Stock
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Percentage of share purchased as part of asset acquisition							94.80%
Ownership interest percentage							5.20%
Cullinan Florentine Corp \| Series B Preferred Units
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Gross proceeds		$ 8,100,000
Additional shares issued		7,500,000
MICA \| HLBV
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Losses attributed to noncontrolling interests				700,000	200,000		$ 1,100,000	500,000
MICA \| Series A Senior Preferred Stock
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Gross proceeds	$ 8,800,000		$ 7,100,000
Percentage of share purchased as part of asset acquisition							53.50%
Ownership interest percentage							46.50%
Purchase of shares	6,700,000		5,400,000
MICA \| Series A Senior Preferred Stock \| Other Existing Investors
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Gross proceeds	$ 1,200,000		$ 900,000
Purchase of shares	900,000		700,000
Cullinan Pearl Corp \| HLBV
Common Stock And Noncontrolling Interest In Subsidiaries [Line Items]
Losses attributed to noncontrolling interests				$ 0	$ (500,000)		$ (300,000)	$ 1,200,000

Equity-Based Compensation - Schedule of Assumptions Used to Estimate Fair value of Market-Based RSUs Granted (Details)	3 Months Ended
	Jun. 30, 2022 $ / shares
Share-Based Payment Arrangement, Recognized Amount [Abstract]
Stock price	$ 12.98
Volatility	82.50%
Remaining term (years)	2 years 8 months 12 days
Risk-free rate	2.90%
Expected dividend yield	0.00%

Equity-Based Compensation - Schedule of Equity-based Compensation Expense Categories In Consolidated Statements of Operations and Comprehensive Income (Loss) (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total equity-based compensation	$ 8,608	$ 4,165	$ 15,173	$ 7,673
Research and Development Expense
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total equity-based compensation	4,379	2,293	7,039	3,862
General and Administrative
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total equity-based compensation	$ 4,229	$ 1,872	$ 8,134	$ 3,811

Related Party Transactions - Additional Information (Details) - USD ($)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Related Party Transaction [Line Items]
Royalty percentage	1.00%
Royalties under obligation	$ 0
MPM Oncology Charitable Foundation, Inc.
Related Party Transaction [Line Items]
Royalty percentage	0.50%
UBS Optimus Foundation
Related Party Transaction [Line Items]
Royalty percentage		0.50%

Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Tax Disclosure [Abstract]
Income tax expense	$ 66,070	$ 0	$ 46,502	$ 0

- Definition

Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References + Details

Commitment and Contingencies (Additional Information) (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Indemnification Agreement [Member]
Loss Contingencies [Line Items]
Accrued Liabilities	$ 0	$ 0

Leases - Additional Information (Details) $ in Millions	1 Months Ended	3 Months Ended		6 Months Ended
Leases - Additional Information (Details) $ in Millions	Dec. 31, 2017 ft²	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)
Lessee Lease Description [Line Items]
Operating Lease expense		$ 0.1		$ 0.3
Rent expense under the prior lease accounting standard			$ 0.2		$ 0.3
Operating lease commence date	Feb. 01, 2018
Operating lease expiration date				Jun. 30, 2024
Massachusetts
Lessee Lease Description [Line Items]
Operating lease rentable area \| ft²	7,531

Leases - Supplemental Cash Flow Information Relating to Leases (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Leases [Abstract]
Operating Lease Payments Proceeds	$ 303
ROU asset obtained in exchange for an operating lease liability	$ 1,311

Leases - Summary of Future Minimum Payments Due Under Operating Lease (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Lessee, Operating Lease, Liability, to be Paid [Abstract]
Remainder of 2022	$ 305
2023	618
2024	313
Future minimum payments due under operating lease	1,236
Less: imputed interest	(107)
Total lease liabilities at present value	1,129
Lease liabilities, current	533	$ 0
Operating lease liabilities, net of current portion	$ 596	$ 0

Leases - Summary of Weighted Average Remaining Lease Terms and Discount Rates (Details)	Jun. 30, 2022
Leases [Abstract]
Weighted-average remaining lease term (years)	2 years
Weighted-average discount rate	9.50%

Earnings per Share - Summary of Calculation of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Numerator:
Net loss attributable to common stockholders of Cullinan	$ 174,898	$ (15,636)	$ 162,800	$ (15,706)
Denominator
Weighted Average Number of Shares Outstanding, Basic	44,873	43,295	44,654	42,713
Dilutive effect of common stock issuable from assumed exercise of equity awards	1,508	0	1,735	0
Weighted Average Number of Shares Outstanding, Diluted	46,381	43,295	46,389	42,713
Earnings (net loss) per share
Earnings Per Share, Basic	$ 3.90	$ (0.36)	$ 3.65	$ (0.37)
Earnings Per Share, Diluted	$ 3.77	$ (0.36)	$ 3.51	$ (0.37)

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

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The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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+ Details

Earnings per Share - Summary of Outstanding Equity Instruments Excluded from Computation of Diluted Net Loss Per Share (Details) - shares	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Shares excluded from computation of diluted net loss per share (in shares)	6,250,000	7,131,000
Restricted Stock Awards
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Shares excluded from computation of diluted net loss per share (in shares)	0	180,000
Stock Options
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Shares excluded from computation of diluted net loss per share (in shares)	6,250,000	6,951,000

Financial Instruments - Summary of Fair Value of Financial Assets Measured on Recurring Basis (Details) - Recurring - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	$ 353,563	$ 59,774
Total short-term investments	257,432	230,692
Total long-term investments	43,182	140,397
Assets Fair Value Disclosure, Total	654,177	430,863
Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	353,563	59,774
Total short-term investments	0	0
Total long-term investments	0	0
Assets Fair Value Disclosure, Total	353,563	59,774
Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	0	0
Total short-term investments	257,432	230,692
Total long-term investments	43,182	140,397
Assets Fair Value Disclosure, Total	300,614	371,089
Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	0	0
Total short-term investments	0	0
Total long-term investments	0	0
Assets Fair Value Disclosure, Total	0	0
U.S. Government Notes
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	61,456	17,998
Total long-term investments	0	20,089
U.S. Government Notes \| Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	0	0
Total long-term investments	0	0
U.S. Government Notes \| Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	61,456	17,998
Total long-term investments	0	20,089
U.S. Government Notes \| Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	0	0
Total long-term investments	0	0
Cash
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	293,193	35,925
Cash \| Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	293,193	35,925
Cash \| Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	0	0
Cash \| Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	0	0
Money Market Funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	60,370	23,849
Money Market Funds \| Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	60,370	23,849
Money Market Funds \| Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	0	0
Money Market Funds \| Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total cash and cash equivalents	0	0
Corporate Notes
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	131,080	98,547
Total long-term investments	43,182	117,272
Corporate Notes \| Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	0	0
Total long-term investments	0	0
Corporate Notes \| Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	131,080	98,547
Total long-term investments	43,182	117,272
Corporate Notes \| Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	0	0
Total long-term investments	0	0
Commercial Paper
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	61,915	114,147
Commercial Paper \| Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	0	0
Commercial Paper \| Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	61,915	114,147
Commercial Paper \| Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	0	0
Asset-backed Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	2,981
Total long-term investments		3,036
Asset-backed Securities \| Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	0
Total long-term investments		0
Asset-backed Securities \| Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	2,981
Total long-term investments		3,036
Asset-backed Securities \| Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total short-term investments	$ 0
Total long-term investments		$ 0